Software requirements, server side

OS: OS-independent, tested only on Linux, Windows 10 Professional and Windows Server 2012 R2
Java: JDK 1.8
Apache Tomcat 8.5+

Make sure that you follow the installation steps carefully:

https://tomcat.apache.org/tomcat-8.5-doc/appdev/installation.html
MySQL 5.1 - 5.7 or Oracle 11g or 12c for the internal registration database, and theoretically any JDBC-compatible DBMS for the configured upstream connection

Check the installation guide for make the DBSM deployment easier.

Oracle: https://docs.oracle.com/cd/E11882_01/nav/portal_11.htm

MySQL: https://dev.mysql.com/doc/mysql-installation-excerpt/5.7/en/
Configured SMTP mail server for e-mail feedback on registration
JChem Oracle Cartridge is not needed

Software requirements, client side

Java: JRE 1.6 - 1.8 (needed when using MarvinSketch applet in all browsers, and in Internet Explorer 11 also for the file uploads)
Web browser: a recent version of Mozilla Firefox, Google Chrome, Safari, or Internet Explorer 11+
ChemDraw 14 or above has to be installed locally (which installs the browser plugins) if chosen as a structure editor

Depends mainly on the database size
At least 2-4 cores are recommended
4-8 GB RAM or more, at least 3 GB should be provided explicitly for the Tomcat JVM.
Cca 500 MB disk space for the application, additional 1 GB during deployment for temporary files; data storage disk space requirements highly depend on the number of structures, approximately 5 GB / 1 M structures

Standard office hardware that can run Java applets and a modern browser with JavaScript support with a decent performance
At least 4 GB RAM suggested if large (> 10000 structures) SD files are processed during bulk upload
Recommended minimum display resolution 1366x768