General Comments

If an action has more than one options but none of them is specified by the user, the action with default option will be performed.

If the output format contains atom coordinates (e.g., mrv, sdf, mol, etc.), and the standardizer action changes any atom coordinate, a built-in clean action will be performed at the end of the standardization process according to the following:

• If the input format is in 0D (e.g., SMILES), the built-in clean action is "full clean".

• If the input format is in 2D (e.g., mrv), the built-in clean action is "partial clean".

• If the input format is in 3D (e.g., mrv), the built-in clean action is "clean3D".

The order of actions in a standardizer configuration is important since the output of the first transformation will become the input of the second one, and so on.

Keep in mind that numerous actions rely on substructure search, where the proper substructure definition has key importance.